The potential roles of neurotrophins in male reproduction

被引:40
|
作者
Li, Chunjin [1 ]
Zhou, Xu [1 ]
机构
[1] Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Anim Embryo Engn, Changchun 130062, Jilin Province, Peoples R China
关键词
NERVE-GROWTH-FACTOR; HUMAN EJACULATED SPERMATOZOA; TYROSINE KINASE RECEPTOR; MALE SEX DETERMINATION; RAT TESTIS; MESSENGER-RNA; GERM-CELL; SIGNALING PATHWAYS; PROTEIN EXPRESSION; EMBRYONIC TESTIS;
D O I
10.1530/REP-12-0466
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neurotrophins are a family of polypeptide growth factors that are required for the proliferation, differentiation, survival, and death of neuronal cells. A growing body of evidence suggests that they may have broader physiological roles in various non-neuronal tissues. The testicles are complex non-neuronal organs in which diverse cell types interact to achieve correct spermatogenesis. Both neurotrophins and their receptors have been detected in various cell types from mammalian testes, suggesting that neurotrophins may regulate or mediate intercellular communication within this organ. This review summarizes the existing data on the cellular distribution and possible biological roles of neurotrophins in the testes. The data reported in the literature indicate that neurotrophins affect somatic cell growth and spermatogenesis and imply that they play a role in regulating testicular development and male reproduction.
引用
收藏
页码:R89 / R95
页数:7
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