A Review of Direct-acting Oral Anticoagulants and Their Use in Solid Organ Transplantation

被引：1

作者：

Rimsans, Jessica ^{[1
]}

Sylvester, Katelyn ^{[1
]}

Kim, Miae ^{[2
]}

Connors, Jean M. ^{[3
,4
]}

Gabardi, Steven ^{[4
,5
]}

机构：

[1] Brigham & Womens Hosp, Dept Pharm Serv, 75 Francis St, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Div Cardiol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA

[4] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Dept Transplant Surg, 75 Francis St, Boston, MA 02115 USA

来源：

TRANSPLANTATION | 2022年 / 106卷 / 11期

关键词：

PROTHROMBIN COMPLEX CONCENTRATE; HEPARIN-INDUCED THROMBOCYTOPENIA; NONVALVULAR ATRIAL-FIBRILLATION; CONSENSUS DECISION PATHWAY; DRUG-DRUG INTERACTIONS; WARFARIN REVERSAL; CARDIOPULMONARY BYPASS; CALCINEURIN INHIBITORS; VENOUS THROMBOEMBOLISM; PULMONARY-EMBOLISM;

D O I：

10.1097/TP.0000000000004195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Direct-acting oral anticoagulant (DOAC) use has increased dramatically since their introduction because of the growing evidence of proven efficacy and enhanced safety compared with warfarin and the low-molecular-weight heparins in the general population. Unfortunately, there is a dearth of quality data regarding the safety and efficacy of the DOACs in patients awaiting organ transplant and those who received a solid organ transplant. This review aims to evaluate the available literature and considerations regarding anticoagulation use in transplant recipients, focusing on preoperative, perioperative, and postoperative DOAC use.

引用

页码：2143 / 2154

页数：12

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