ESR1 polymorphisms and risk of preeclampsia

Objective Polymorphism of estrogen receptor alpha (ESR1) polymorphisms plays an important role in the adaptation of increased uterine blood flow during gestation. Published data on the association between the ESR1 polymorphisms and preeclampsia risk are controversial. A meta-analysis was performed to assess whether the polymorphisms of ESR1 are associated with preeclampsia risk. Methods Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for ESR1 polymorphisms and preeclampsia were appropriately derived from fixed-effects or random-effects models. Results A total of seven studies were enrolled in this meta-analysis. The pooled analyses revealed that both ESR1 PvuII and XbaI polymorphisms were not associated with preeclampsia risk. No significant heterogeneity among the including studies was found in all models of ESR1 PvuII and XbaI polymorphisms. Conclusions Present meta-analysis demonstrates that ESR1 polymorphisms may not be correlated to preeclampsia risk.