Sauroine, an Alkaloid from Huperzia saururus with Activity in Wistar Rats in Electrophysiological and Behavioral Assays Related to Memory Retention

被引：20

作者：

Vallejo, Mariana G. ^{[1
]}

Ortega, Maria G. ^{[1
]}

Cabrera, Jose L. ^{[1
]}

Carlini, Valeria P. ^{[2
]}

de Barioglio, Susana Rubiales ^{[2
]}

Almiron, Romina S. ^{[2
]}

Ramirez, Oscar A. ^{[2
]}

Agnese, Mariel ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Dept Farm, Fac Ciencias Quim, Inst Multidisciplinario Biol Vegetal IMBIV CONICE, RA-5000 Cordoba, Argentina

[2] Univ Nacl Cordoba, Dept Farmacol, Fac Ciencias Quim, RA-5000 Cordoba, Argentina

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 01期

关键词：

LONG-TERM POTENTIATION; SYNAPTIC-TRANSMISSION; HIPPOCAMPUS;

D O I：

10.1021/np800151v

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.

引用

页码：156 / 158

页数：3

共 4 条

[1] Sauroine -: a novel Lycopodium alkaloid from Huperzia saururus
Ortega, MG
Agnese, AM
Cabrera, JL
TETRAHEDRON LETTERS, 2004, 45 (38) : 7003 - 7005
[2] Huperzia saururus increases memory retention in rats
Vallejo, M. G.
Ortega, M. G.
Cabrera, J. L.
Carlini, V. P.
de Barioglio, S. Rubiales
Agnese, A. M.
JOURNAL OF ETHNOPHARMACOLOGY, 2007, 111 (03) : 685 - 687
[3] Interaction between the antioxidant activity of curcumin and cholinergic system on memory retention in adult male Wistar rats
Sarlak, Zeynab
Oryan, Shahrbanoo
Moghaddasi, Mehrnoush
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2015, 18 (04) : 398 - 403
[4] Antidiabetic Activity of an Alkaloid (4a-Methyl-5-(6-Methylhept-5-En-1-Yl)Octahydro-1H-Cyclopenta[A]Pyridazine) Isolated From Lumnitzera racemosa in Streptozotocin-Induced Diabetic Wistar Rats
Ranjana, Ranjana
Singh, Deepak Kumar
Jadhav, Bhaskar Laxman
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION, 2022, 12 (03) : 351 - 357

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