Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives

被引：7

作者：

Krainz, Tanja ^{[1
]}

Chow, Sharon ^{[1
]}

Korica, Natasa ^{[2
]}

Bernhardt, Paul V. ^{[1
]}

Boyle, Glen M. ^{[2
]}

Parsons, Peter G. ^{[2
]}

Davies, Huw M. L. ^{[3
]}

Williams, Craig M. ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[2] PO Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Brisbane, Qld 4029, Australia

[3] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 01期

基金：

美国国家科学基金会; 澳大利亚研究理事会;

关键词：

Cycloaddition; Furans; Rhodium; Homogeneous catalysis; Antitumor agents; CYCLOPROPANATION COPE REARRANGEMENT; PROTEIN-KINASE-C; ASYMMETRIC-SYNTHESIS; ORGANIC-SYNTHESIS; 7-MEMBERED RINGS; NATURAL-PRODUCTS; INGENOL; THAPSIGARGINS; STRATEGY; VINYLCARBENOIDS;

D O I：

10.1002/ejoc.201501271

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method to directly access the bicyclo[5.3.0]decane core was achieved by rhodium-catalyzed reaction of a novel donor-acceptor cyclopentenyl diazocarboxylate with a variety of furans. As this motif is commonly found within bioactive antitumor natural products, selected systems were further manipulated and evaluated against cancer cell lines sensitive to protein kinase C (PKC) activation.

引用

页码：41 / 44

页数：4

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