No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population

Several investigations suggest that complexin may be a schizophrenia-SUsceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Tell and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respectively, were selected. Only one htSNP (rs930047 in CPLX2) in allele-wise analysis showed significance, and even this disappeared with an increased sample size (563 cases and 519 controls: P=.757). Haplotype-wise analysis showed a weak association with a combination of htSNPs in CPLX2 (P=.0424), but this may be a result of type I error due to multiple testing. Our results suggest that complexin genes do not play a major role in sell izophrenia in Japanese patients. (c) 2005 Elsevier B.V. All rights reserved.