Cardiovascular risk after bariatric surgery for obesity
被引:77
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作者:
Batsis, John A.
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Mayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Dept Med, Rochester, MN USAMayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Batsis, John A.
[1
,2
]
Sarr, Michael G.
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机构:
Mayo Clin, Coll Med, Dept Surg, Rochester, MN USAMayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Sarr, Michael G.
[3
]
Collazo-Clavell, Maria L.
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机构:
Mayo Clin, Coll Med, Dept Med, Rochester, MN USA
Mayo Clin, Coll Med, Div Endocrinol & Metab, Rochester, MN USAMayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Collazo-Clavell, Maria L.
[2
,4
]
Thomas, Randal J.
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h-index: 0
机构:
Mayo Clin, Coll Med, Dept Med, Rochester, MN USA
Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN USAMayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Thomas, Randal J.
[2
,5
]
Romero-Corral, Abel
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机构:
Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN USAMayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Romero-Corral, Abel
[5
]
Somers, Virend K.
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机构:
Mayo Clin, Coll Med, Dept Med, Rochester, MN USA
Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN USAMayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Somers, Virend K.
[2
,5
]
Lopez-Jimenez, Francisco
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Mayo Clin, Coll Med, Dept Med, Rochester, MN USA
Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN USAMayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
Lopez-Jimenez, Francisco
[2
,5
]
机构:
[1] Mayo Clin, Coll Med, Div Primary Care Internal Med, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Med, Rochester, MN USA
[3] Mayo Clin, Coll Med, Dept Surg, Rochester, MN USA
[4] Mayo Clin, Coll Med, Div Endocrinol & Metab, Rochester, MN USA
[5] Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN USA
Obese patients have an increased prevalence of cardiovascular (CV) risk factors, which improve with bariatric surgery, but whether bariatric surgery reduces long-term CV events remains ill defined. A systematic review of published. research was conducted, and CV risk models were applied in a validation cohort previously published. A standardized MEDLINE search using terms associated with obesity, bariatric surgery, and CV risk factors identified 6 test studies. The validation cohort consisted of a population-based, historical cohort of 197 patients who underwent Roux-en-Y gastric bypass and 163 control patients, identified through the Rochester Epidemiology Project. Framingham and Prospective Cardiovascular Munster Heart Study (PROCAM) risk scores were applied to calculate 10-year CV risk. In the validation cohort, absolute 10-year Framingham risk score for CV events was lower at follow-up in the bariatric surgery group (7.0% to 3.5%, p <0.001) compared with controls (7.1% to 6.5%, p = 0.13), with an intergroup absolute difference in risk reduction of 3% (p <0.001). PROCAM risk in the bariatric surgery group decreased from 4.1% to 2.0% (p <0.001), whereas the control group exhibited only a modest decrease (4.4% to 3.8%, p = 0.08). Using mean data from the validation study, the trend and directionality in risk was similar in the Roux-en-Y group. The test studies confirmed the directionality of CV risk, with estimated relative risk reductions for bariatric surgery patients ranging from 18% to 79% using the Framingham risk score compared with 8% to 62% using the PROCAM risk score. In conclusion, bariatric surgery predicts long-term decreases in CV risk in obese patients. (C) 2008 Elsevier Inc. All rights reserved.
机构:
Ohio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USAOhio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA
Michalsky, Marc P.
Inge, Thomas H.
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机构:
Univ Colorado, Denver, CO 80202 USA
Univ Colorado, Childrens Hosp Colorado, Aurora, CO USAOhio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA
Inge, Thomas H.
Jenkins, Todd M.
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机构:
Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USAOhio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA
Jenkins, Todd M.
Xie, Changchun
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机构:
Univ Cincinnati, Cincinnati, OH USAOhio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA
Xie, Changchun
Courcoulas, Anita
论文数: 0引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Med Ctr, Pittsburgh, PA USAOhio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA
Courcoulas, Anita
Helmrath, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USAOhio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA