2-Phenyl-2,3-dihydrobenzo[d] thiazole: A Mild, Efficient, and Highly Active in situ Generated Chemoselective Reducing Agent for the One-Pot Synthesis of 5-Monoalkylbarbiturates in Water

被引：7

作者：

Kalita, Subarna Jyoti ^{[1
]}

Deka, Dibakar Chandra ^{[1
]}

机构：

[1] Univ Gauhati, Dept Chem, Gauhati 781014, Assam, India

来源：

SYNLETT | 2018年 / 29卷 / 04期

关键词：

5-monoalkylbarbiturates; benzothiazoline; transfer hydrogenation; aqueous media; metal- and catalyst-free; BARBITURIC-ACID; ORGANIC-SYNTHESIS; C-ALKYLATION; BENZOTHIAZOLINE; CONVULSANT; ANTICONVULSANT; ENHANCEMENT; HYPNOTICS; REDUCTION; CATALYST;

D O I：

10.1055/s-0036-1591725

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

. A metal- and catalyst-free reductive alkylation protocol for the one-pot synthesis of 5-monoalkylbarbiturates from barbituric acids and aldehydes using the in situ generated chemoselective reducing agent 2-phenyl-2,3-dihydrobenzo[d] thiazole from 2-aminothiophenol and benzaldehyde is described. The notable advantages of the protocol are operational simplicity, mild reaction conditions, high yield, short reaction time, and simple workup and purification process which make it highly attractive.

引用

页码：477 / 482

页数：6

共 4 条

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[2] Highly efficient synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitriles through a one-pot palladium-catalyzed coupling reaction/cyclization in water
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[4] An Efficient One-pot Two-component Protocol for Regio- and Chemoselective Synthesis of 5-Aryloyl-1,3,7,9-tetraalkyl-2,8-dithioxo-2,3,8,9-tetrahydro-1H-pyrano[2,3-d:6,5-d']dipyrimidine-4,6(5H,7H)-diones
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