Nonionic surfactant vesicles for delivery of RNAi therapeutics

被引：29
|
作者：
Paecharoenchai, Orapan [1 ,2 ]
Teng, Lesheng [3 ]
Yung, Bryant C. [2 ]
Teng, Lirong [3 ]
Opanasopit, Praneet [1 ]
Lee, Robert J. [2 ,3 ]
机构：
[1] Silpakorn Univ, Pharmaceut Dev Green Innovat Grp, Nakhon Pathom 73000, Thailand
[2] Ohio State Univ, Coll Pharm, Div Pharmaceut, Columbus, OH 43210 USA
[3] Jilin Univ, Coll Life Sci, Changchun 130021, Jilin, Peoples R China
来源：
NANOMEDICINE | 2013年 / 8卷 / 11期
关键词：
gene delivery; niosome; nonionic surfactant vesicle; siRNA delivery; DRUG-DELIVERY; GENE DELIVERY; TOPICAL DELIVERY; SIRNA DELIVERY; IN-VITRO; NANOPARTICLE FORMULATIONS; CATIONIC LIPOSOMES; ORAL DELIVERY; NIOSOMES; CARRIERS;
D O I：
10.2217/nnm.13.155
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
RNAi is a promising potential therapeutic approach for many diseases. A major barrier to its clinical translation is the lack of efficient delivery systems for siRNA. Among nonviral vectors, nonionic surfactant vesicles (niosomes) have shown a great deal of promise in terms of their efficacy and toxicity profiles. Nonionic surfactants have been shown to be a superior alternative to phospholipids in several studies. There is a large selection of surfactants with various properties that have been incorporated into niosomes. Therefore, there is great potential for innovation in terms of nisome composition. This article summarizes recent advancements in niosome technology for the delivery of siRNA.
引用
收藏
页码：1865 / 1873
页数：9
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