Age-related changes in rat genioglossus, geniohyoid and masseter muscles

被引：5

作者：

Kaneko, Syuhei ^{[1
]}

Iida, Ryo-hei ^{[1
]}

Suga, Takeo ^{[1
]}

Morito, Mitsuhiko ^{[1
]}

Yamane, Akira ^{[2
]}

机构：

[1] Tsurumi Univ, Sch Dent Med, Dept Geriatr Dent, Yokohama, Kanagawa 2308501, Japan

[2] Tsurumi Univ, Sch Dent Med, Dept Biophys, Yokohama, Kanagawa 2308501, Japan

来源：

GERODONTOLOGY | 2014年 / 31卷 / 01期

关键词：

genioglossus muscle; geniohyoid muscle; myosin heavy chain; rat; ADVERSE CHANGES; FIBER TYPES; DIAPHRAGM; PRESSURE; PROTEINS; ISOFORMS; GENE;

D O I：

10.1111/ger.12004

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectivesThe aim of this study was to elucidate age-related changes from adult to middle age in the contractile properties of the masseter, genioglossus and geniohyoid muscles of the rat. Materials and MethodsWe analysed the expressions of myosin heavy chain (MyHC) mRNAs and proteins as indicators of the contractile properties in these muscles obtained from rats at 6, 12, 18 and 24months of age using real-time PCR and SDS-PAGE. ResultsWe found no marked age-related changes in the expressions of MyHC mRNAs and proteins in rat masseter and geniohyoid muscles, suggesting that the biological ageing process does not affect contractile properties in these muscles. However, we found a decrease in the expression of MyHC IIb mRNA with ageing in the rat genioglossus muscle, suggesting that biological ageing process induces at least some fast-to-slow myofibre phenotype transition. ConclusionThe biological ageing process from adult to middle age appears to differentially affect different types of craniofacial muscles.

引用

页码：56 / 62

页数：7

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