Three-Component Condensation for the Construction of Novel Spirooxindoles

被引：3

作者：

Ji, Fei ^{[1
]}

Sun, Mu ^{[1
]}

Lv, Mei-fang ^{[1
]}

Yi, Wen-bin ^{[1
]}

Cai, Chun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Jiangsu, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 03期

关键词：

multicomponent reaction; spirooxindoles; 3+2] cycloaddition; CuAAC reaction; triazoles; AROMATIC CARBOXYLIC-ACIDS; ALKYL ISOCYANIDES; ONE-POT; DIMETHYL ACETYLENEDICARBOXYLATE; DIALKYL ACETYLENEDICARBOXYLATES; STEREOSELECTIVE-SYNTHESIS; SPIROCYCLIC OXINDOLES; ACETYLENIC ESTERS; TERMINAL ALKYNES; FACILE SYNTHESIS;

D O I：

10.1055/s-0032-1316836

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route for the synthesis of novel spirooxindoles from isocyanides, dialkyl acetylenedicarboxylates, and N-substituted isatylidene derivatives through [3+2] cycloaddition has been developed. This method has several advantages, such as high regioselectivity, high yields, readily available starting materials, and one-pot operations. The synthetic alkyne-containing spirooxindoles could also be used in the selective synthesis of triazole-containing spirocyclic compounds using a copper azide-alkyne cycloaddition (CuAAC) reaction.

引用

页码：375 / 381

页数：7

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