Flow-Directed Assembly of Block Copolymer Vesicles in the Lab-on-a-Chip

被引：37
|
作者：
Wang, Chih-Wei [1 ]
Bains, Aman [1 ]
Sinton, David [2 ]
Moffitt, Matthew G. [1 ]
机构：
[1] Univ Victoria, Dept Chem, Victoria, BC V8W 3V6, Canada
[2] Univ Toronto, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada
来源：
LANGMUIR | 2012年 / 28卷 / 45期
基金：
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词：
SHEAR-FLOW; MICELLES; DIBLOCK; MORPHOLOGIES; PARTICLES;
D O I：
10.1021/la303655s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We demonstrate a microfluidic approach to the production of block copolymer vesicles via flow directed self assembly in a segmented gas-liquid device. Chemical conditions that favor spherical micelles in the bulk are found to yield a nearly pure population of vesicles on a chip-a transformation of two full morphological steps-because of a coalescence mechanism enabled by high shear. The production of polymeric vesicles via top-down control in a microfluidic device enables new processing routes to applications including drug delivery formulations in the lab-on-a-chip.
引用
收藏
页码：15756 / 15761
页数：6
相关论文
共 50 条
  • [1] Flow-Directed Block Copolymer Micelle Morphologies via Microfluidic Self-Assembly
    Wang, Chih-Wei
    Sinton, David
    Moffitt, Matthew G.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (46) : 18853 - 18864
  • [2] Microstructural ordering of nanofibers in flow-directed assembly
    Gao EnLai
    Wang ShiJun
    Duan ChuanHua
    Xu ZhiPing
    SCIENCE CHINA-TECHNOLOGICAL SCIENCES, 2019, 62 (09) : 1545 - 1554
  • [3] Directed peptide microarray fabrication for lab-on-a-chip applications
    Voelker, Alden E.
    Viswanathan, Rajesh
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [4] Microstructural ordering of nanofibers in flow-directed assembly
    GAO EnLai
    WANG ShiJun
    DUAN ChuanHua
    XU ZhiPing
    Science China(Technological Sciences), 2019, 62 (09) : 1545 - 1554
  • [5] Microstructural ordering of nanofibers in flow-directed assembly
    GAO EnLai
    WANG ShiJun
    DUAN ChuanHua
    XU ZhiPing
    Science China(Technological Sciences) , 2019, (09) : 1545 - 1554
  • [6] Microstructural ordering of nanofibers in flow-directed assembly
    EnLai Gao
    ShiJun Wang
    ChuanHua Duan
    ZhiPing Xu
    Science China Technological Sciences, 2019, 62 : 1545 - 1554
  • [7] Flow-Directed Loading of Block Copolymer Micelles with Hydrophobic Probes in a Gas-Liquid Microreactor
    Wang, Chih-Wei
    Bains, Aman
    Sinton, David
    Moffitt, Matthew G.
    LANGMUIR, 2013, 29 (26) : 8385 - 8394
  • [8] Directed assembly of block copolymer films
    Karim, Alamgir
    Berry, B.
    Yager, K.
    Bosse, A.
    Douglas, J. F.
    Jones, R. L.
    Briber, R. M.
    Kim, H. C.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 237
  • [9] The Effect of Surface Micropatterns on the Flow in a Lab-on-a-Chip with Nanowires
    Qavi, Imtiaz
    Sooriyaarachchi, Dilshan
    Tan, George
    MANUFACTURING LETTERS, 2023, 35 : 174 - 183
  • [10] The Effect of Surface Micropatterns on the Flow in a Lab-on-a-Chip with Nanowires
    Qavi, Imtiaz
    Sooriyaarachchi, Dilshan
    Tan, George
    MANUFACTURING LETTERS, 2023, 35 (174-183) : 174 - 183
12345