hit selection;
visualization;
interactive visualization;
screening;
open source;
HIGH-THROUGHPUT;
HIT SELECTION;
NORMALIZATION;
ASSAYS;
D O I:
10.1177/2472555217731983
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
Screening is a methodology widely used in biological and biomedical research. There are numerous visualization methods to validate screening data quality but very few visualization applications capable of hit selection. Here, we present MightyScreen (mightyscreen.net), a novel web-based application designed for visual data evaluation as well as visual hit selection. We believe MightyScreen is an intuitive and interactive addition to conventional hit selection methods. We also provide study cases showing how MightyScreen is used to visually explore screening data and make hit selections.
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Haas, Christian P.
Luebbesmeyer, Maximilian
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Luebbesmeyer, Maximilian
Jin, Edward H.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Jin, Edward H.
McDonald, Matthew A.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
McDonald, Matthew A.
Koscher, Brent A.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Koscher, Brent A.
Guimond, Nicolas
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Guimond, Nicolas
Di Rocco, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Div Pharmaceut, Chem & Pharmaceut Dev, D-13353 Berlin, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Di Rocco, Laura
Kayser, Henning
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-40789 Monheim, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Kayser, Henning
Leweke, Samuel
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Enabling Funct Div, Appl Math, D-51368 Leverkusen, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Leweke, Samuel
Niedenfu, Sebastian
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Computat Life Sci, D-40789 Monheim, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Niedenfu, Sebastian
Nicholls, Rachel
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Computat Life Sci, D-40789 Monheim, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Nicholls, Rachel
Greeves, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Greeves, Emily
Barber, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Weed Control Chem, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Barber, David M.
Hillenbrand, Julius
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Pharmaceut Div, Chem & Pharmaceut Dev, D-42117 Wuppertal, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Hillenbrand, Julius
Volpin, Giulio
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Volpin, Giulio
Jensen, Klavs F.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Haas, Christian P.
Luebbesmeyer, Maximilian
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USA
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Luebbesmeyer, Maximilian
Jin, Edward H.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Jin, Edward H.
McDonald, Matthew A.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
McDonald, Matthew A.
Koscher, Brent A.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Koscher, Brent A.
Guimond, Nicolas
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-40789 Monheim, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Guimond, Nicolas
Di Rocco, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Pharmaceut Div, Chem & Pharmaceut Dev, D-13353 Berlin, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Di Rocco, Laura
Kayser, Henning
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-40789 Monheim, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Kayser, Henning
Leweke, Samuel
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Enabling Funct Div, Appl Math, D-51368 Leverkusen, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Leweke, Samuel
Niedenfuehr, Sebastian
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Res & Dev, Crop Sci Div, Computat Life Sci, D-40789 Monheim, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Niedenfuehr, Sebastian
Nicholls, Rachel
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Res & Dev, Crop Sci Div, Computat Life Sci, D-40789 Monheim, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Nicholls, Rachel
Greeves, Emily
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Greeves, Emily
Barber, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Weed Control Chem, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Barber, David M.
Hillenbrand, Julius
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Pharmaceut Div, Chem & Pharmaceut Dev, D-42117 Wuppertal, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Hillenbrand, Julius
Volpin, Giulio
论文数: 0引用数: 0
h-index: 0
机构:
Bayer AG, Crop Sci Div, Res & Dev, Small Mol Technol, D-65926 Frankfurt, GermanyMIT, Dept Chem Engn, Cambridge, MA 02139 USA
Volpin, Giulio
Jensen, Klavs F.
论文数: 0引用数: 0
h-index: 0
机构:
MIT, Dept Chem Engn, Cambridge, MA 02139 USAMIT, Dept Chem Engn, Cambridge, MA 02139 USA
机构:
Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA
Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
Med Univ S Carolina, Coll Grad Studies, Charleston, SC 29425 USA
Med Univ S Carolina, Coll Med, Med Scientist Training Program, Charleston, SC 29425 USAMed Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA
Mullins, Christopher R.
Hanlon, Colleen A.
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA
Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
Med Univ S Carolina, Coll Grad Studies, Charleston, SC 29425 USAMed Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA
机构:
Harvard T H Chan Sch Publ Hlth, Dept Environm Hlth, 677 Huntington Ave, Boston, MA 02215 USA
Liberty Mutual Res Inst Safety, Hopkinton, MA USAHarvard T H Chan Sch Publ Hlth, Dept Environm Hlth, 677 Huntington Ave, Boston, MA 02215 USA
Dixon, Philippe C.
Loh, Jonathan J.
论文数: 0引用数: 0
h-index: 0
机构:
Medicus Corda, Montreal, PQ, CanadaHarvard T H Chan Sch Publ Hlth, Dept Environm Hlth, 677 Huntington Ave, Boston, MA 02215 USA
Loh, Jonathan J.
Michaud-Paquette, Yannick
论文数: 0引用数: 0
h-index: 0
机构:
McGill Univ, McGill Res Ctr Phys Activ & Hlth, Montreal, PQ, Canada
McGill Univ, Dept Kinesiol & Phys Educ, Montreal, PQ, CanadaHarvard T H Chan Sch Publ Hlth, Dept Environm Hlth, 677 Huntington Ave, Boston, MA 02215 USA
Michaud-Paquette, Yannick
Pearsall, David J.
论文数: 0引用数: 0
h-index: 0
机构:
McGill Univ, McGill Res Ctr Phys Activ & Hlth, Montreal, PQ, Canada
McGill Univ, Dept Kinesiol & Phys Educ, Montreal, PQ, CanadaHarvard T H Chan Sch Publ Hlth, Dept Environm Hlth, 677 Huntington Ave, Boston, MA 02215 USA