Stereoselective synthesis of the C3-C12 subunit of laulimalide

被引：3
|
作者：
Raghavan, Sadagopan [1 ]
Samanta, Pradip Kumar [1 ]
机构：
[1] Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 04期
关键词：
Laulimalide; Organocatalysis; Ferrier type rearrangement; BIOLOGICAL EVALUATION; (-)-LAULIMALIDE; AGENT; ISOLAULIMALIDE; ALKYLATION; ANALOGS;
D O I：
10.1016/j.tetlet.2013.12.040
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A stereoselective synthesis of the C3-C12 subunit of the tumor growth inhibitors laulimalide is disclosed. The key steps of the synthesis include asymmetric alkylation using Oppolzer's protocol and an asymmetric hetero-Diels-Alder reaction using Jacobsen's catalyst. Substrate controlled diastereoselective Luche reduction followed by Ferrier type reactions are other key steps. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：913 / 915
页数：3
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