Engineering CAR-T Cells for Next-Generation Cancer Therapy

被引：391
|
作者：
Hong, Mihe [1 ]
Clubb, Justin D. [1 ]
Chen, Yvonne Y. [1 ,2 ,3 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Parker Inst Canc Immunotherapy Ctr, Los Angeles, CA 90095 USA
来源：
CANCER CELL | 2020年 / 38卷 / 04期
关键词：
CHIMERIC-ANTIGEN-RECEPTOR; FIBROBLAST ACTIVATION PROTEIN; NATURAL-KILLER-CELLS; ANTITUMOR EFFICACY; SUICIDE-GENE; TUMOR MICROENVIRONMENT; 4-1BB COSTIMULATION; CHECKPOINT BLOCKADE; SAFETY SWITCH; TGF-BETA;
D O I：
10.1016/j.ccell.2020.07.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
T cells engineered to express chimeric antigen receptors (CARs) with tumor specificity have shown remarkable success in treating patients with hematologic malignancies and revitalized the field of adoptive cell therapy. However, realizing broader therapeutic applications of CAR-T cells necessitates engineering approaches on multiple levels to enhance efficacy and safety. Particularly, solid tumors present unique challenges due to the biological complexity of the solid-tumor microenvironment (TME). In this review, we highlight recent strategies to improve CAR-T cell therapy by engineering (1) the CAR protein, (2) T cells, and (3) the interaction between T cells and other components in the TME.
引用
收藏
页码：473 / 488
页数：16
相关论文
共 50 条
  • [1] The next-generation CAR-T therapy landscape
    Malvika Verma
    Kyle Obergfell
    Shana Topp
    Val Panier
    John Wu
    [J]. Nature Reviews Drug Discovery, 2023, 22 : 776 - 777
  • [2] The next-generation CAR-T therapy landscape
    Verma, Malvika
    Obergfell, Kyle
    Topp, Shana
    Panier, Val
    Wu, John
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2023, 22 (10) : 776 - 777
  • [3] Engineering Next-Generation CAR-T Cells for Better Toxicity Management
    Andrea, Alain E.
    Chiron, Andrada
    Bessoles, Stephanie
    Hacein-Bey-Abina, Salima
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (22) : 1 - 25
  • [4] Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism
    Gao, Torahito A.
    Chen, Yvonne Y.
    [J]. ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, 2022, 13 : 193 - 216
  • [5] RegCAR-T™: Enabling next-generation CAR-T therapy
    Zhang, Xu
    Tang, Ke
    Song, Qingxuan
    Chen, Si
    Kasbek, Christopher
    Wang, Tianjiao
    Huang, Jun
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [6] CAR-T Cells: Next Generation Cancer Therapeutics
    Balakrishnan, Ashwini
    [J]. JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE, 2018, 98 (01) : 21 - 31
  • [7] CAR-T Cells: Next Generation Cancer Therapeutics
    Ashwini Balakrishnan
    [J]. Journal of the Indian Institute of Science, 2018, 98 : 21 - 31
  • [8] Current state and next-generation CAR-T cells in multiple myeloma
    Manier, Salomon
    Ingegnere, Tiziano
    Escure, Guillaume
    Prodhomme, Chloe
    Nudel, Morgane
    Mitra, Suman
    Facon, Thierry
    [J]. BLOOD REVIEWS, 2022, 54
  • [9] Engineering Next-Generation T Cells for Cancer Immunotherapy
    Chen, Yvonne Y.
    [J]. BIOPHYSICAL JOURNAL, 2020, 118 (03) : 319A - 319A
  • [10] Next generation CAR-T cell therapy for solid tumors
    Tamada, Koji
    [J]. CANCER SCIENCE, 2021, 112 : 1022 - 1022
12345