Accurate measurement and clinical significance of urinary transforming growth factor-beta

被引：40
|
作者：
Tsakas, Sotiris [1 ]
Goumenos, Dimitrios S.
机构：
[1] Univ Patras, Biol Lab, Dept Biol, GR-26500 Patras, Greece
[2] Univ Hosp Patras, Patras, Greece
来源：
AMERICAN JOURNAL OF NEPHROLOGY | 2006年 / 26卷 / 02期
关键词：
transforming growth factor-beta(1); enzyme immunoassay; proteinuria; glomerular injury;
D O I：
10.1159/000093178
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Transforming growth factor beta(1), (TGF-beta(1)) is the main modulator of the healing process after tissue injury. In the kidney, if TGF-beta(1) release is not switched off, extracellular matrix components (ECM) are accumulated and tissue fibrosis occurs. Urinary TGF-beta(1) levels reflect its renal production and it has been determined in various types of glomerular disease. In this review, a critical analysis of the different immunoassays that have been used for the measurement of TGF-beta(1) in the urine is presented and the importance of the serial determination of urinary TGF-beta(1) levels in patients with various types of renal disease is discussed. Copyright (c) 2006 S. Karger AG, Basel.
引用
收藏
页码：186 / 193
页数：8
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