Enantioselective semi-preparative HPLC of two 2-arylpropionic acids on glycopeptides containing chiral stationary phases

被引：12
|
作者：
Alcaro, S
D'Acquarica, I
Gasparrini, F
Misiti, D
Pierini, M
Villani, C
机构：
[1] Univ Roma La Sapienza, Dip Studi Chim Tecnol Sostanze Biologicament Atti, I-00185 Rome, Italy
[2] Univ Magna Graecia di Catanzaro, Dipartimento Sci Farmacobiol, I-88021 Roccelletta Di Borgia, CZ, Italy
[3] Dip Sci Farm, I-66013 Chieti, Italy
来源：
TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 01期
关键词：
D O I：
10.1016/S0957-4166(02)00046-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We describe a new enantioselective HPLC procedure for the direct semi-preparative resolution of two unmodified 2-arylpropionic acids. The method is based on the use of novel laboratory-made chiral stationary phases (CSPs) containing macrocyclic glycopeptide antibiotics, such as teicoplanin and A-40,926, covalently bonded to silica gel microparticles. The new CSPs showed high enantioselectivities and broad applicabilities for separations on a semi-preparative scale. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：69 / 75
页数：7
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