Animal Challenge Models of Henipavirus Infection and Pathogenesis

被引：71

作者：

Geisbert, Thomas W. ^{[1
]}

Feldmann, Heinz ^{[2
]}

Broder, Christopher C. ^{[3
]}

机构：

[1] Univ Texas Med Branch, Galveston Natl Lab, Dept Microbiol & Immunol, Galveston, TX 77550 USA

[2] NIAID, Virol Lab, Rocky Mt Labs, Div Intramural Res,NIH, Hamilton, MT 59840 USA

[3] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Emerging Infect Dis Grad Program, Bethesda, MD 20814 USA

来源：

HENIPAVIRUS: ECOLOGY, MOLECULAR VIROLOGY, AND PATHOGENESIS | 2012年 / 359卷

关键词：

NIPAH-VIRUS-INFECTION; EQUINE MORBILLIVIRUS PNEUMONIA; TO-PERSON TRANSMISSION; HENDRA VIRUS; HAMSTER MODEL; PTEROPID BATS; ENCEPHALITIS OUTBREAK; FATAL ENCEPHALITIS; WEST-BENGAL; PIG-FARMERS;

D O I：

10.1007/82_2012_208

中图分类号：

Q17 [水生生物学];

学科分类号：

071004 ;

摘要：

The henipaviruses, Hendra virus (HeV), and Nipah virus (NiV), are enigmatic emerging pathogens that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75% and there are no vaccines or treatments approved for human use. A number of species of animals including guinea pigs, hamsters, cats, ferrets, pigs, and African green monkeys have been employed as animal models of human henipavirus infection. Here, we review the development of animal models for henipavirus infection, discuss the pathology and pathogenesis of these models, and assess the utility of each model to recapitulate important aspects of henipavirus-mediated disease seen in humans.

引用

页码：153 / 177

页数：25

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