Pathogenesis of venous ulcer

被引：38
|
作者：
Comerota, Anthony [1 ]
Lurie, Fedor [1 ]
机构：
[1] Jobst Vasc Inst, Toledo, OH 43606 USA
来源：
SEMINARS IN VASCULAR SURGERY | 2015年 / 28卷 / 01期
关键词：
SMOOTH-MUSCLE-CELLS; COLLAGEN TYPE-III; VARICOSE-VEINS; LEG ULCER; OUTFLOW OBSTRUCTION; GENERAL-POPULATION; SUPERFICIAL VEINS; C677T MUTATION; INSUFFICIENCY; DISEASE;
D O I：
10.1053/j.semvascsurg.2015.07.003
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The underlying pathophysiology of venous ulceration is venous hypertension, which initiates a complex cascade of cellular humeral events that are then magnified by genetic factors. Hemodynamic abnormalities are features of primary and secondary chronic venous diseases that lead to disease progression. Through a sequence of events, some patients develop venous leg ulcers, if the process is not interrupted. The exact science of the pathophysiology of the progression of chronic venous disease to venous leg ulcers is still in its infancy, but the framework for future study has been established. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：6 / 14
页数：9
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