Studies on the secondary metabolite of the soft coral Lobophytum sp.

被引：0
|
作者：
He, XX [1 ]
Su, JY
Zeng, LM
Yang, XP
Liang, YJ
机构：
[1] Zhongshan Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China
[2] Sun Yat Sen Univ Med Sci, Inst Canc, Guangzhou 510060, Peoples R China
来源：
ACTA CHIMICA SINICA | 2002年 / 60卷 / 02期
关键词：
Lobophytum sp; steroid; glycoside; cytotoxicity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Five steroidal glycosides (1) similar to (5) have been isolated from die soft coral Lobophytum sp., collected from Sanya Bay, Hainan Island. Base on the spectroscopic methods, their structures were determined to be 3'-O-acetyl-4-O- [beta-D-xylo-pyranosyl-oxy]-pregn-20-en-3beta, 4alpha-diol (1), 4-O-[beta-D-xylo-pyranosyl-oxy]-pregn-20-en-3beta,4alpha-diol (2), 4'-O-acetyl-4-O-[beta-D-xylo-pyranosyl-oxy]-pregn-20-en-3beta,4alpha-diol (3), 4'-O-acetyl-4-O-[beta-D-arabino-pyranosyl-oxy]-pregn-20-en-3beta, 4alpha-diol ( 4), and 4-O-[beta-D-arabino-pyranosyl-oxy]-pregn-20-en-3beta,4alpha-diol (5). Among them, 1 is a new compound. Bioassay showed that 1, 2 and 5 displayed cytotoxicity against human SKMG-4, Hep-G2 and CNE2 cell lines in vitro.
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页码：334 / 337
页数：4
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