Discovery of an irreversible PI3Kα-specific Inhibitor

被引：0
|
作者：
Qiao, Lixin [1 ]
Nacht, Mariana [1 ]
Sheets, Michael P. [1 ]
St Martin, Thia [1 ]
Labenski, Matthew [1 ]
Mazdiyasni, Hormoz [1 ]
Zhu, Zhendong [1 ]
Chaturvedi, Prasoon [1 ]
Bhavsar, Deepa [1 ]
Niu, Deqiang [1 ]
Westlin, William [1 ]
Petter, Russell [1 ]
Singh, Juswinder [1 ]
机构：
[1] Avila Therapeut Inc, Waltham, MA USA
来源：
CANCER RESEARCH | 2011年 / 71卷
关键词：
D O I：
10.1158/1538-7445.AM2011-4482
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4482
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Discovery of a novel phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor against hematologic malignancies and theoretical studies on its PI3Kγ-specific binding mechanisms
    Zhu, Jingyu
    Ke, Ke
    Xu, Lei
    Jin, Jian
    [J]. RSC ADVANCES, 2019, 9 (35): : 20207 - 20215
  • [2] Discovery of a novel and potent mutant-selective inhibitor of PI3Kα
    Gao, Mingming
    Qi, Chao
    Li, Zhentian
    Fan, Qipeng
    Wang, Liyang
    Zhou, Fei
    You, Lin
    Zheng, Hewen
    Li, Yu
    Wu, Liangxing
    Yao, Wenqing
    Liu, Phillip C.
    [J]. CANCER RESEARCH, 2024, 84 (06)
  • [3] Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases
    Erra, Montse
    Taltavull, Joan
    Javier Bernal, Francisco
    Francisco Caturla, Juan
    Carrascal, Marta
    Pages, Lluis
    Mir, Marta
    Espinosa, Sonia
    Gracia, Jordi
    Dominguez, Maria
    Sabate, Mar
    Paris, Stephane
    Maldonado, Monica
    Hernandez, Begona
    Bravo, Monica
    Calama, Elena
    Miralpeix, Montserrat
    Lehner, Martin D.
    Calbet, Marta
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (21) : 9551 - 9567
  • [4] Discovery of AZD8835, a potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of PIK3CA-dependent cancers
    Barlaam, Bernard
    Cosulich, Sabina
    Delouvrie, Benedicte
    Fitzek, Martina
    Germain, Herve
    Green, Stephen
    Harris, Craig S.
    Hudson, Kevin
    Lambert-van der Brempt, Christine
    Lamorlette, Maryannick
    Antoine, Le Griffon
    Morgentin, Remy
    Ouvry, Gilles
    Page, Ken
    Pasquet, Georges
    Ruston, Linette
    Saleh, Twana
    Vautier, Michel
    Ward, Lara
    [J]. CANCER RESEARCH, 2015, 75
  • [5] Discovery of GDC-0084: A BBB penetrating PI3K/mTOR inhibitor
    Heffron, Timothy
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [6] Discovery of the potent PI3K/mTOR dual inhibitor PF-04979064
    Cheng, Hengmiao
    Bagrodia, Shubha
    Bailey, Simon
    Baxi, Sangita M.
    Goulet, Lance
    Guo, Lisa
    Hoffman, Jacqui
    Johnson, Ted O.
    Johnson, Ted W.
    Li, Chunze
    Li, John
    Liu, Kevin
    Liu, Zhengyu
    Marx, Matthew A.
    Paderes, Gigi
    Sun, Shaoxian
    Walls, Marlena
    Wells, Peter A.
    Yang, Anle
    Yin, Min-Jean
    Zhu, Jingjiang
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [7] Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma
    Perry, Matthew W. D.
    Bjorhall, Karin
    Bold, Peter
    Brulls, Mikael
    Borjesson, Ulf
    Carlsson, Johan
    Chang, Hui-Fang Amy
    Chen, Yunhua
    Eriksson, Anders
    Fihn, Britt-Marie
    Fransson, Rebecca
    Fredlund, Linda
    Ge, Hongbin
    Huang, Haijuan
    Karabelas, Kostas
    Bergstrom, Eva Lamm
    Lever, Sarah
    Lindmark, Helena
    Mogemark, Mickael
    Nikitidis, Antonios
    Palmgren, Anna-Pia
    Pemberton, Nils
    Petersen, Jens
    Blomqvist, Mio Rodrigo
    Smith, Reed W.
    Thomas, Matthew J.
    Ullah, Victoria
    Tyrchan, Christian
    Wennberg, Tiiu
    Eriksson, Annika Westin
    Yang, Wenzhen
    Zhao, Shuchun
    Oster, Linda
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (12) : 8053 - 8075
  • [8] Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)
    Zheng, Zhaohua
    Pinson, Jo-Anne
    Mountford, Simon J.
    Orive, Stephanie
    Schoenwaelder, Simone M.
    Shackleford, David
    Powell, Andrew
    Nelson, Erin M.
    Hamilton, Justin R.
    Jackson, Shaun P.
    Jennings, Ian G.
    Thompson, Philip E.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 122 : 339 - 351
  • [9] Discovery of CH5132799, a novel class I PI3K inhibitor
    Ohwada, J.
    Ebiike, H.
    Kawada, H.
    Tsukazaki, M.
    Nakamura, M.
    Morikami, K.
    Morita, K.
    Yoshida, M.
    Kondoh, O.
    Shimma, N.
    [J]. EJC SUPPLEMENTS, 2010, 8 (07): : 41 - 41
  • [10] Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
    Till, Kathleen J.
    Abdullah, Mariah
    Alnassfan, Tahera
    Janet, Gallardo Zapata
    Marks, Thomas
    Coma, Silvia
    Weaver, David T.
    Pachter, Jonathan A.
    Pettitt, Andrew R.
    Slupsky, Joseph R.
    [J]. SCIENTIFIC REPORTS, 2023, 13 (01)
12345