Role of the transforming growth factor- signaling pathway in the pathogenesis of colorectal cancer

被引：34

作者：

Soleimani, Atena ^{[1
,2
]}

Pashirzad, Mehran ^{[1
]}

Avan, Amir ^{[3
,4
]}

Ferns, Gordon A. ^{[5
]}

Khazaei, Majid ^{[3
,6
]}

Hassanian, Seyed Mahdi ^{[1
,3
]}

机构：

[1] Mashhad Univ Med Sci, Dept Clin Biochem, Fac Med, Mashhad 1394491388, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran

[4] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Razavi Khorasan, Iran

[5] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England

[6] Mashhad Univ Med Sci, Dept Med Physiol, Fac Med, Mashhad, Razavi Khorasan, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 06期

关键词：

colorectal cancer; transforming growth factor- receptors; transforming growth factor- signaling; TGF-BETA; ULCERATIVE-COLITIS; CELL-MIGRATION; RISK-FACTOR; MESENCHYMAL TRANSITION; AKT PATHWAYS; RECEPTOR; SMAD7; METASTASIS; INHIBITION;

D O I：

10.1002/jcb.28331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transforming growth factor- (TGF-) signaling pathway plays an important role in cancer cell proliferation, growth, metastasis, and apoptosis. It has been shown that TGF- acts as a tumor suppressor in the early stages of the disease, and as a tumor promoter in its late stages. Mutations in the TGF- signaling components, the TGF- receptors and cytoplasmic signaling transducers, are frequently observed in colorectal carcinomas. Exploiting specific TGF- receptor agonist and antagonist with antitumor properties may be a way of controlling cancer progression. This review summarizes the regulatory role of TGF- signaling in the pathogenesis of colorectal cancer.

引用

页码：8899 / 8907

页数：9

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