Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows

被引：8

作者：

Pitts, Katie L. ^{[1
]}

Fenech, Marianne ^{[1
,2
]}

机构：

[1] Univ Ottawa, Dept Chem & Biol Engn, Ottawa, ON K1N 6N5, Canada

[2] Univ Ottawa, Dept Mech Engn, Ottawa, ON K1N 6N5, Canada

来源：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2013年 / 74期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Bioengineering; Issue; 74; Biophysics; Chemical Engineering; Mechanical Engineering; Biomedical Engineering; Medicine; Anatomy; Physiology; Cellular Biology; Molecular Biology; Hematology; Blood Physiological Phenomena; Hemorheology; Hematocrit; flow characteristics; flow measurement; flow visualization; rheology; Red blood cells; cross correlation; micro blood flows; microfluidics; microhemorheology; microcirculation; velocimetry; visualization; imaging; MICROCIRCULATION;

D O I：

10.3791/50314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Micro-particle image velocimetry (mu PIV) is used to visualize paired images of micro particles seeded in blood flows. The images are cross-correlated to give an accurate velocity profile. A protocol is presented for mu PIV measurements of blood flows in microchannels. At the scale of the microcirculation, blood cannot be considered a homogeneous fluid, as it is a suspension of flexible particles suspended in plasma, a Newtonian fluid. Shear rate, maximum velocity, velocity profile shape, and flow rate can be derived from these measurements. Several key parameters such as focal depth, particle concentration, and system compliance, are presented in order to ensure accurate, useful data along with examples and representative results for various hematocrits and flow conditions.

引用

页数：8

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