High-density genotyping and linkage disequilibrium in the human genome using chromosome 22 as a model

被引：4
|
作者：
Remm, M
Metspalu, A
机构：
[1] Univ Tartu, Estonian Bioctr, EE-51010 Tartu, Estonia
[2] Univ Tartu, Inst Mol & Cellular Biol, EE-51010 Tartu, Estonia
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(01)00285-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Technology and genetics have advanced to the point where genotyping thousands of individuals at thousands of marker locations around the whole human genome is possible. The whole-genome scan for detection of complex disease genes is a widely discussed topic. We review some of the recent high-density genotyping experiments and discuss related details, particularly the extent and variability of linkage disequilibrium. We also discuss the quality of single nucleotide polymorphisms (SNPs) in public databases and its consequences to the number of SNPs required for large-scale genotyping projects.
引用
收藏
页码：24 / 30
页数：7
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