Transition-Metal-Free Oxyfluorination of Olefinic Amides for the Synthesis of Fluorinated Heterocycles

被引：53

作者：

Zhao, Jing-Feng

Duan, Xin-Hua

Yang, Hua

Guo, Li-Na ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Chem, Sch Sci, Xian 710049, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 21期

关键词：

OXIDATIVE RING-CLOSURE; ANION PHASE-TRANSFER; 2-SUBSTITUTED QUINAZOLINES; MEDICINAL CHEMISTRY; RADICAL AMINOFLUORINATION; ASYMMETRIC FLUORINATION; UNACTIVATED ALKENES; EFFICIENT SYNTHESIS; AQUEOUS-MEDIA; STYRENES;

D O I：

10.1021/acs.joc.5b01909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of fluorinated 4H-3,1-benzoxazines and iminoisobenzofurans have been synthesized through the electrophilic fluorocyclizadon of olefinic amides. This methodology is highlighted by its mild conditions, wide substrate scope, and good functional group tolerance.

引用

页码：11149 / 11155

页数：7

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