The cluster-randomized trial

被引：3
|
作者：
Giraudeau, B [1 ]
机构：
[1] Fac Med Tours, Inserm CIC 202, F-37032 Tours, France
来源：
M S-MEDECINE SCIENCES | 2004年 / 20卷 / 03期
关键词：
D O I：
10.1051/medsci/2004203363
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Within the framework of a clinical trial, one is sometimes brought to randomize groups of subjects rather than the subjects themselves. This type of experimental design has methodological consequences of importance (in particular biostatistical consequences) and can limit the extrapolation of the results. A cluster randomized trial is thus justified only if the context or the question of interest imposes it and biostatistical issues have then to be handled in a rigorous way.
引用
收藏
页码：363 / +
页数：5
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