NMDA receptor-dependent and -independent long-term depression in the CA1 region of the adult rat hippocampus in vivo

被引：55
|
作者：
Kemp, N [1 ]
Bashir, ZI [1 ]
机构：
[1] UNIV BRISTOL,SCH MED SCI,DEPT ANAT,BRISTOL BS8 1TD,AVON,ENGLAND
来源：
NEUROPHARMACOLOGY | 1997年 / 36卷 / 03期
基金：
英国惠康基金;
关键词：
long-term depression (LTD); CA1; hippocampus; NMDA; plasticity;
D O I：
10.1016/S0028-3908(96)90015-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have investigated different stimulus parameters in an attempt to induce long-term depression (LTD) in the CA1 region of adult rat hippocampus in vitro. Whereas 900 stimuli delivered at 1 Hz failed to induce LTD, 900 stimuli when delivered as 450 pairs (50 msec inter-stimulus interval) at 1 Hz induced significant and stable N-methyl-D-aspartate (NMDA) receptor-dependent LTD. However, 900 paired stimuli at 1 Hz induced LTD which was only partly blocked by the NMDA receptor antagonist, D-2-amino-5-phosphonopentanoate (AP5). (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：397 / 399
页数：3
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