New Advances in Urea Transporter UT-A1 Membrane Trafficking

被引：5
|
作者：
Chen, Guangping [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA 30322 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 05期
基金：
美国国家卫生研究院;
关键词：
lipid rafts; glycosylation; accessory proteins; SNARE protein; cytoskeleton protein; WATER CHANNEL AQUAPORIN-2; LIPID RAFTS; EPITHELIAL-CELLS; N-GLYCOSYLATION; COLLECTING DUCT; SUBCELLULAR-LOCALIZATION; SNARE PROTEINS; F-ACTIN; VASOPRESSIN; BINDING;
D O I：
10.3390/ijms140510674
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The vasopressin-regulated urea transporter UT-A1, expressed in kidney inner medullary collecting duct (IMCD) epithelial cells, plays a critical role in the urinary concentrating mechanisms. As a membrane protein, the function of UT-A1 transport activity relies on its presence in the plasma membrane. Therefore, UT-A1 successfully trafficking to the apical membrane of the polarized epithelial cells is crucial for the regulation of urea transport. This review summarizes the research progress of UT-A1 regulation over the past few years, specifically on the regulation of UT-A1 membrane trafficking by lipid rafts, N-linked glycosylation and a group of accessory proteins.
引用
收藏
页码：10674 / 10682
页数：9
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