BDNF-270 C>T polymorphisms might be associated with stroke type and BDNF-196 G>A corresponds to early neurological deficit in hemorrhagic stroke

被引：31
|
作者：
Mirowska-Guzel, Dagmara [1 ,2 ]
Gromadzka, Grazyna [1 ,2 ]
Czlonkowski, Andrzej [2 ]
Czlonkowska, Anna [1 ,2 ]
机构：
[1] Inst Psychiat & Neurol, Dept Neurol 2, Stroke Unit, PL-02957 Warsaw, Poland
[2] Med Univ Warsaw, Dept Expt & Clin Pharmacol, PL-00927 Warsaw, Poland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 249卷 / 1-2期
关键词：
Stroke; BDNF; Polymorphism; Neurological deficit; Clinical outcome; NEUROTROPHIC FACTOR BDNF; ACUTE ISCHEMIC-STROKE; ACTIVITY-DEPENDENT SECRETION; INJURY FOLLOWING TRAUMA; VAL66MET POLYMORPHISM; INFECTION; VARIANT; SUSCEPTIBILITY; COMPLICATIONS; RECOVERY;
D O I：
10.1016/j.jneuroim.2012.04.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Genetic factors might be involved in stroke prognosis, however the role of brain-derived neurotrophic factor (BDNF) in stroke recovery is unknown. We have studied BDNF - 196 G>A and - 270 C>T polymorphisms in ischemic and hemorrhagic stroke and their impact on stroke prognosis. There was higher occurrence of BDNF - 270 CC genotype in patients with hemorrhagic than ischemic stroke (96% versus 86%, p = 0.0495). In hemorrhagic stroke BDNF - 196 GG carriers scored better in NIHSS at admission (14.23 versus 21.00, p = 0.0192) and after 7 days (8.60 versus 15.00, p =0.0408) of onsets. None of the determined polymorphisms had any impact on 30 day early outcome in ischemic and hemorrhagic stroke. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：71 / 75
页数：5
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