Use of dupilumab in a patient with atopic dermatitis, severe asthma, andHIVinfection

被引：10
|
作者：
Brodska, Petra [1 ]
Panzner, Petr [2 ]
Sedlacek, Dalibor [3 ]
Terl, Milan [4 ]
Cetkovska, Petra [1 ]
机构：
[1] Charles Univ Prague, Dept Dermatol & Venereol, Edvarda Benese 12, Plzen 30599, Czech Republic
[2] Charles Univ Prague, Inst Immunol & Allergol, Plzen, Czech Republic
[3] Charles Univ Prague, Dept Infect Dis, Plzen, Czech Republic
[4] Charles Univ Prague, Dept Pneumol & Phthisiol, Plzen, Czech Republic
来源：
DERMATOLOGIC THERAPY | 2020年 / 33卷 / 06期
关键词：
asthma; atopic dermatitis; dupilumab; HIV; PLACEBO; ROLES;
D O I：
10.1111/dth.14159
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Dupilumab is a monoclonal antibody against interleukin 4 (IL-4) receptor alpha that blocks signaling from IL-4 and IL-13, essential mediators of T helper 2 (Th2) pathway. To date, all clinical trials investigating the use of dupilumab excluded patients with human immunodeficiency virus. Herein, we describe the safe and successful use of dupilumab in a patient with atopic dermatitis, severe therapy resistant asthma, and HIV infection.
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页数：3
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