NGF-induced neurite outgrowth in PC12 cells is independent of calcium entry through L-type calcium channels

被引：11
|
作者：
Lichvarova, Lucia [1 ]
Jaskova, Katarina [1 ]
Lacinova, Lubica [1 ]
机构：
[1] Slovak Acad Sci, VVCE Biomembranes, Inst Mol Physiol & Genet, Bratislava, Slovakia
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 2012年 / 31卷 / 04期
关键词：
PC12; cells; L-type calcium channels; Dihydropyridines; Neurite outgrowth; NERVE GROWTH-FACTOR; RAT PHEOCHROMOCYTOMA; SIGNALING PATHWAYS; EXPRESSION; ACTIVATION; ELEVATION; WINDOW; LINE;
D O I：
10.4149/gpb_2012_054
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuronal growth factor (NGF) induces neurodifferentiation of PC12 cells into cholinergic neurons-like cells. It was shown that intracellular Ca2+ ions participate in regulation of the differentiation of PC12 cells. We tested whether L-type calcium channels contribute to Ca2+ entry which supports neurite outgrowth accompanying NGF-activated differentiation process. Development of morphological changes did correlate with increase of functional expression of L-type calcium channels. However, inhibition of L-type calcium channels by 1 mu M of isradipine did not affect significantly an NGF-activated neurite outgrowth.
引用
收藏
页码：473 / 478
页数：6
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