Safety and Efficacy of BMS-791325, a Non-Nucleoside NS5B Polymerase Inhibitor, Combined with Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Patients Infected with Hepatitis C Virus Genotype 1

被引：0
|
作者：
Tatum, Harvey A. [1 ]
Thuluvath, Paul J. [2 ]
Lawitz, Eric [3 ]
Martorell, Claudia [4 ]
Cohen, Stanley M. [5 ]
Rustgi, Vinod K. [6 ]
Ravendhran, Natarajan [7 ]
Ghalib, Reem H. [8 ]
Hanson, John [9 ]
Zamparo, Joann [10 ]
Zhao, Jing [11 ]
Treitel, Michelle [12 ]
Hughes, Eric A. [12 ]
机构：
[1] Opt Hlth Res, Tulsa, OK USA
[2] Mercy Med Ctr, Baltimore, MD USA
[3] Univ Texas Hlth Sci Ctr San Antonio, Texas Liver Inst, San Antonio, TX 78229 USA
[4] Res Inst, Springfield, MA USA
[5] Univ Hosp Cleveland, Case Western Med Ctr, Cleveland, OH 44106 USA
[6] Metropolitan Res, Arlington, VA USA
[7] Digest Dis Associates, Baltimore, MD USA
[8] Texas Clin Res Inst, Arlington, TX USA
[9] Charlotte Gastroenterol & Hepatol, Charlotte, NC USA
[10] Bristol Myers Squibb Co, Wallingford, CT 06492 USA
[11] Bristol Myers Squibb Co, Hopewell, NY USA
[12] Bristol Myers Squibb Co, Princeton, NJ USA
来源：
HEPATOLOGY | 2013年 / 58卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
1126
引用
收藏
页码：759A / 760A
页数：2
相关论文
共 50 条
  • [1] A PHASE 2A STUDY OF BMS-791325, AN NS5B POLYMERASE INHIBITOR, WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN IN TREATMENT-NAIVE PATIENTS WITH GENOTYPE 1 CHRONIC HEPATITIS C INFECTION
    Tatum, H.
    Thuluvath, P.
    Lawitz, E.
    Martorell, C. T.
    Demicco, M.
    Cohen, S.
    Rustgi, V.
    Ravendhran, N.
    Ghalib, R.
    Hanson, J.
    Zamparo, J.
    Yang, R.
    Hughes, E.
    Cooney, E.
    JOURNAL OF HEPATOLOGY, 2012, 56 : S460 - S460
  • [2] Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase
    Rigat, Karen L.
    Lu, Hao
    Wang, Ying-Kai
    Argyrou, Argyrides
    Fanslau, Caroline
    Beno, Brett
    Wang, Yi
    Marcinkeviciene, Jovita
    Ding, Min
    Gentles, Robert G.
    Gao, Min
    Abell, Lynn M.
    Roberts, Susan B.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (48) : 33456 - 33468
  • [3] Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase
    Lemm, Julie A.
    Liu, Mengping
    Gentles, Robert G.
    Ding, Min
    Voss, Stacey
    Pelosi, Lenore A.
    Wang, Ying-Kai
    Rigat, Karen L.
    Mosure, Kathleen W.
    Bender, John A.
    Knipe, Jay O.
    Colonno, Richard
    Meanwell, Nicholas A.
    Kadow, John F.
    Santone, Kenneth S.
    Roberts, Susan B.
    Gao, Min
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (06) : 3485 - 3495
  • [4] Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
    Gentles, Robert G.
    Ding, Min
    Bender, John A.
    Bergstrom, Carl P.
    Grant-Young, Katharine
    Hewawasam, Piyasena
    Hudyma, Thomas
    Martin, Scott
    Nickel, Andrew
    Regueiro-Ren, Alicia
    Tu, Yong
    Yang, Zhong
    Yeung, Kap-Sun
    Zheng, Xiaofan
    Chao, Sam
    Sun, Jung-Hui
    Beno, Brett R.
    Camac, Daniel M.
    Chang, Chong-Hwan
    Gao, Mian
    Morin, Paul E.
    Sheriff, Steven
    Tredup, Jeff
    Wan, John
    Witmer, Mark R.
    Xie, Dianlin
    Hanumegowda, Umesh
    Knipe, Jay
    Mosure, Kathy
    Santone, Kenneth S.
    Parker, Dawn D.
    Zhuo, Xiaoliang
    Lemm, Julie
    Liu, Mengping
    Pelosi, Lenore
    Rigat, Karen
    Voss, Stacey
    Wang, Yi
    Wang, Ying-Kai
    Colonno, Richard J.
    Gao, Min
    Roberts, Susan B.
    Gao, Qi
    Ng, Alicia
    Meanwell, Nicholas A.
    Kadow, John F.
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (05) : 1855 - 1879
  • [5] Potency and Resistance Analysis of Hepatitis C Virus NS5B Polymerase Inhibitor BMS-791325 on All Major Genotypes
    Liu, Mengping
    Tuttle, Maria
    Gao, Min
    Lemm, Julie A.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (12) : 7416 - 7423
  • [6] ANTIVIRAL EFFICACY OF THE NS3 PROTEASE INHIBITOR, GS-9451, NON-NUCLEOSIDE NS5b INHIBITOR, TEGOBUVIR, AND PEGYLATED INTERFERON PLUS RIBAVIRIN IN TREATMENT-NAIVE GENOTYPE 1 HEPATITIS C INFECTED PATIENTS
    Pol, S.
    Jablkowski, M.
    Trenkle, J. D.
    Kanwar, B.
    Bekele, B. N.
    Subramanian, M.
    McHutchison, J. G.
    Flamm, S. L.
    Muir, A. J.
    JOURNAL OF HEPATOLOGY, 2013, 58 : S31 - S31
  • [7] Daclatasvir combined with peginterferon alfa-2a and ribavirin in Japanese patients infected with hepatitis C genotype 1
    Izumi, Namiki
    Yokosuka, Osamu
    Kawada, Norifumi
    Osaki, Yukio
    Yamamoto, Kazuhide
    Sata, Michio
    Ishikawa, Hiroki
    Ueki, Tomoko
    Hu, Wenhua
    McPhee, Fiona
    Hughes, Eric A.
    Kumada, Hiromitsu
    ANTIVIRAL THERAPY, 2014, 19 (05) : 501 - 510
  • [8] Dasabuvir: A Non-Nucleoside Inhibitor of NS5B for the Treatment of Hepatitis C Virus Infection
    Gentile, Ivan
    Buonomo, Antonio R.
    Borgia, Guglielmo
    REVIEWS ON RECENT CLINICAL TRIALS, 2014, 9 (02) : 115 - 123
  • [9] Randomized Controlled Trial of Danoprevir Plus Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection
    Marcellin, Patrick
    Cooper, Curtis
    Balart, Luis
    Larrey, Dominique
    Box, Terry
    Yoshida, Eric
    Lawitz, Eric
    Buggisch, Peter
    Ferenci, Peter
    Weltman, Martin
    Labriola-Tompkins, Emily
    Le Pogam, Sophie
    Najera, Isabel
    Thomas, Denise
    Hooper, Gregory
    Shulman, Nancy S.
    Zhang, Ying
    Navarro, Mercidita T.
    Lim, Chin Yin
    Brunda, Michael
    Terrault, Norah A.
    Yetzer, Ellen S.
    GASTROENTEROLOGY, 2013, 145 (04) : 790 - +
  • [10] PRECLINICAL CHARACTERIZATION OF THE HEPATITIS C VIRUS NS5B POLYMERASE NON-NUCLEOSIDE INHIBITOR BILB 1941
    Kukolj, G.
    Anderson, P. C.
    Boes, M.
    Cordingley, M. G.
    Coulombe, R.
    Garneau, M.
    Gillard, J.
    Goulet, S.
    Jolicoeur, E.
    Lagace, L.
    Lamarre, D.
    Laplante, S.
    Marquis, M.
    McKercher, G.
    Pellerin, C.
    Poupart, M. -A.
    Beaulieu, P. L.
    JOURNAL OF HEPATOLOGY, 2011, 54 : S480 - S480
12345