Interleukin-16;
gastric cancer;
polymorphisms;
Chinese population;
HELICOBACTER-PYLORI INFECTION;
PROMOTER POLYMORPHISM;
GENETIC-POLYMORPHISM;
COLORECTAL-CANCER;
PROSTATE-CANCER;
INDIAN ENIGMA;
EXPRESSION;
CARCINOMA;
TUMOR;
CYTOKINES;
D O I:
10.7314/APJCP.2013.14.9.5269
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Aim: We conducted a case-control matched study to investigate the role of IL-16 gene polymorphisms, rs4072111, rs1131445, rs4778889 and rs11556218, in the risk of gastric cancer in a Chinese population, also performing subgroup analysis by subsites. Methods: To test the hypothesis of involvement, we analyzed the four SNPs of IL16 in 347 cancer patients and 368 controls. Demographic data and other information were collected using a newly designed questionnaire. Genotyping of IL16 (rs4072111, rs1131445, rs4778889 and rs11556218) was performed in a 384-well plate format on the MassARRAY (R) platform. Results: In our study, we found the gastric cancer patients were more likely to be male and have a family history of cancer (P < 0.05). We found the rs4778889 CC and rs11556218 GG genotype was significantly associated with 1.97 and 1.84-fold increased risk of non-cardia gastric cancer, while we did not find significant association between the four IL-16 SNPs and cardia gastric cancer. Conclusions: In conclusion, our study indicated that IL-16 rs4778889 CC and rs11556218 GG genotypes are associated with an increased risk of non-cardia gastric cancer in a Chinese population. Our results offer insights into the influence of IL-16 on development of gastric cancer.
机构:
Sichuan Univ, W China Sch Preclin & Forens Med, Dept Forens Biol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Gao, Lin-Bo
Rao, Li
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机构:
Sichuan Univ, W China Hosp, Dept Cardiol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Rao, Li
Wang, Yan-Yun
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机构:
Sichuan Univ, W China Sch Preclin & Forens Med, Dept Immunol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Wang, Yan-Yun
Liang, Wei-Bo
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机构:
Sichuan Univ, W China Sch Preclin & Forens Med, Dept Forens Biol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Liang, Wei-Bo
Li, Cui
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机构:
Sichuan Univ, W China Sch Preclin & Forens Med, Dept Forens Biol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Li, Cui
Xue, Hui
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机构:
Sichuan Univ, W China Sch Preclin & Forens Med, Dept Immunol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Xue, Hui
Zhou, Bin
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Sichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Zhou, Bin
Sun, Hong
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Sichuan Univ, W China Sch Preclin & Forens Med, Dept Immunol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Sun, Hong
Li, Yi
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Sichuan Univ, W China Sch Preclin & Forens Med, Dept Immunol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Li, Yi
Lv, Mei-Li
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机构:
Sichuan Univ, W China Sch Preclin & Forens Med, Dept Immunol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Lv, Mei-Li
Du, Xiao-Jiong
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机构:
Sichuan Univ, W China Hosp, Dept Surg, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
Du, Xiao-Jiong
Zhang, Lin
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Sichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Second Univ Hosp, Lab Mol Translat Med, Chengdu 610041, Sichuan, Peoples R China
机构:
Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R China
Xiong, Jianping
Hu, Haitao
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R China
Hu, Haitao
Kang, Wenzhe
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R China
Kang, Wenzhe
Shao, Xinxin
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h-index: 0
机构:
Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R China
Shao, Xinxin
Li, Yang
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h-index: 0
机构:
Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R China
Li, Yang
Jin, Peng
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机构:
Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R China
Jin, Peng
Tian, Yantao
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h-index: 0
机构:
Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100730, Peoples R China
机构:
Taishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R ChinaTaishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R China
Yang, Hongyun
Han, Yanyan
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机构:
Taishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R ChinaTaishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R China
Han, Yanyan
Wu, Lele
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h-index: 0
机构:
Taishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R ChinaTaishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R China
Wu, Lele
Wu, Chaojun
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h-index: 0
机构:
Taishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R ChinaTaishan Med Univ, Affiliated Hosp, Dept Clin Lab Med, 706 Taian St, Tai An 271000, Shandong, Peoples R China