Variants of Interleukin-16 Associated with Gastric Cancer Risk

被引:19
|
作者
Zhang, Tao [1 ]
Wang, Hui [1 ]
机构
[1] Ctr Hosp Wuhan, Dept Gastrointestinal Surg, Wuhan, Peoples R China
关键词
Interleukin-16; gastric cancer; polymorphisms; Chinese population; HELICOBACTER-PYLORI INFECTION; PROMOTER POLYMORPHISM; GENETIC-POLYMORPHISM; COLORECTAL-CANCER; PROSTATE-CANCER; INDIAN ENIGMA; EXPRESSION; CARCINOMA; TUMOR; CYTOKINES;
D O I
10.7314/APJCP.2013.14.9.5269
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim: We conducted a case-control matched study to investigate the role of IL-16 gene polymorphisms, rs4072111, rs1131445, rs4778889 and rs11556218, in the risk of gastric cancer in a Chinese population, also performing subgroup analysis by subsites. Methods: To test the hypothesis of involvement, we analyzed the four SNPs of IL16 in 347 cancer patients and 368 controls. Demographic data and other information were collected using a newly designed questionnaire. Genotyping of IL16 (rs4072111, rs1131445, rs4778889 and rs11556218) was performed in a 384-well plate format on the MassARRAY (R) platform. Results: In our study, we found the gastric cancer patients were more likely to be male and have a family history of cancer (P < 0.05). We found the rs4778889 CC and rs11556218 GG genotype was significantly associated with 1.97 and 1.84-fold increased risk of non-cardia gastric cancer, while we did not find significant association between the four IL-16 SNPs and cardia gastric cancer. Conclusions: In conclusion, our study indicated that IL-16 rs4778889 CC and rs11556218 GG genotypes are associated with an increased risk of non-cardia gastric cancer in a Chinese population. Our results offer insights into the influence of IL-16 on development of gastric cancer.
引用
收藏
页码:5269 / 5273
页数:5
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