Receptor activator of nuclear factor-κB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds

被引：17

作者：

Qu, Zechao ^{[1
]}

Zhang, Bo ^{[1
]}

Kong, Lingbo ^{[1
]}

Gong, Yining ^{[1
]}

Feng, Mingzhe ^{[1
]}

Gao, Xiangcheng ^{[1
]}

Wang, Dong ^{[1
]}

Yan, Liang ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Honghui Hosp, Dept Spinal Surg, Xian, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

osteoporosis; osteoclastogenesis; RANKL; signaling pathway; natural compounds; RANKL-INDUCED OSTEOCLASTOGENESIS; BONE; OSTEOPOROSIS; DIFFERENTIATION; INHIBITION; KINASE; AKT;

D O I：

10.3389/fphar.2022.1043975

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Osteoclast is a hematopoietic precursor cell derived from the mononuclear macrophage cell line, which is the only cell with bone resorption function. Its abnormal activation can cause serious osteolysis related diseases such as rheumatoid arthritis, Paget's disease and osteoporosis. In recent years, the adverse effects caused by anabolic anti-osteolytic drugs have increased the interest of researchers in the potential therapeutic and preventive effects of natural plant derivatives and natural compounds against osteolytic diseases caused by osteoclasts. Natural plant derivatives and natural compounds have become major research hotspots for the treatment of osteolysis-related diseases due to their good safety profile and ability to improve bone. This paper provides an overview of recent advances in the molecular mechanisms of RANKL and downstream signaling pathways in osteoclast differentiation, and briefly outlines potential natural compounds with antiosteoclast activity and molecular mechanisms.

引用

页数：13

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