Nano-Based Anti-Tubercular Drug Delivery and Therapeutic Interventions in Tuberculosis

被引:9
|
作者
Sharma, Rohit [1 ]
Kaur, Amanpreet [1 ]
Sharma, A. K. [2 ]
Dilbaghi, Neeraj [3 ]
Sharma, Anil K. [1 ]
机构
[1] Maharishi Markandeshwar Univ, Dept Biotechnol, Mullana Ambala 133207, Haryana, India
[2] Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
[3] Guru Jambeshwar Univ Sci & Technol, Dept Bio & Nano Technol, Hisar, Haryana, India
关键词
Nanomedicine; TB; nanocarriers; drugs; drug regimen; EARLY BACTERICIDAL ACTIVITY; MYCOBACTERIUM-TUBERCULOSIS; IN-VITRO; ANTIMYCOBACTERIAL ACTIVITY; ANTITUBERCULAR DRUG; PYRAZINAMIDE RESISTANCE; SECONDARY METABOLITES; BIOLOGICAL EVALUATION; PROTECTIVE EFFICACY; PULMONARY DELIVERY;
D O I
10.2174/1389450116666150804110238
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nanotechnology has shown great promise in health care offering numerous possibilities to significantly improve diagnosis of many dreadful diseases including Tuberculosis (TB). Nanomedicine has made the current drug regimen more effective against diseases particularly TB with attributes like sustained release, increased half life, higher drug concentrations at target sites, reduced toxicity and lesser side effects. However because of the severity of the disease, there is a strong urge to develop better approaches with some concomitant regimens using nano-particles to diagnose, treat and manage TB patients. The current review highlights some of the evolving strategies in the field of nanomedicine particularly drug delivery offering promising alternative for the current TB regimens. The study also emphasizes upon the need to design more effective nanocarriers which are highly specific, biocompatible and biodegradable as well.
引用
收藏
页码:72 / 86
页数:15
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