Experimental Methods to Study the Mechanisms of Interaction of Lipid Membranes with Low-Molecular-Weight Drugs

被引：9
|
作者：
Le-Deygen, I. M. [1 ]
Skuredina, A. A. [1 ]
Kudryashova, E. V. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Chem Dept, Moscow 119991, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2020年 / 46卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
liposomes; IR spectroscopy; EPR spectroscopy; fluorescence methods; differential scanning calorimetry; DIFFERENTIAL SCANNING CALORIMETRY; LIPOSOMES; DOXORUBICIN; FLUORESCENCE; STABILITY; COMPLEXES; RELEASE; FTIR; NANOCRYSTALS; DISSOCIATION;
D O I：
10.1134/S1068162020040123
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The review is devoted to methods for studying how lipid membranes interact with low-molecular-weight drugs. The following methods are considered in the review: IR and EPR spectroscopy, fluorescence analysis, differential scanning calorimetry, and microscopy methods. Methods for characterizing the size and charge of vesicles are also considered: dynamic light scattering and nanoparticle tracking analysis. Methods are divided into those requiring additional labels and label-free. An important objective of the review is to find the optimal research strategy by selecting informative, modern approaches to studying the interactions of drugs with lipid membranes, as well as analyze the latest achievements of instrumental methods.
引用
收藏
页码：480 / 497
页数：18
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