Synthesis of chemicals by metabolic engineering of microbes

被引：93

作者：

Sun, Xinxiao ^{[1
]}

Shen, Xiaolin ^{[1
]}

Jain, Rachit ^{[2
]}

Lin, Yuheng ^{[2
]}

Wang, Jian ^{[2
]}

Sun, Jing ^{[1
]}

Wang, Jia ^{[1
]}

Yan, Yajun ^{[3
]}

Yuan, Qipeng ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

[2] Univ Georgia, Coll Engn, Athens, GA 30602 USA

[3] Univ Georgia, BioChem Engn Program, Coll Engn, Athens, GA 30602 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2015年 / 44卷 / 11期

基金：

美国国家科学基金会; 中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

RECOMBINANT CORYNEBACTERIUM-GLUTAMICUM; L-TYROSINE PRODUCTION; ESCHERICHIA-COLI STRAINS; L-GLUTAMATE PRODUCTION; FATTY-ACID PRODUCTION; AMINO-ACIDS; SACCHAROMYCES-CEREVISIAE; ISOPROPANOL PRODUCTION; BIOSYNTHETIC-PATHWAY; MUCONIC ACID;

D O I：

10.1039/c5cs00159e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metabolic engineering is a powerful tool for the sustainable production of chemicals. Over the years, the exploration of microbial, animal and plant metabolism has generated a wealth of valuable genetic information. The prudent application of this knowledge on cellular metabolism and biochemistry has enabled the construction of novel metabolic pathways that do not exist in nature or enhance existing ones. The hand in hand development of computational technology, protein science and genetic manipulation tools has formed the basis of powerful emerging technologies that make the production of green chemicals and fuels a reality. Microbial production of chemicals is more feasible compared to plant and animal systems, due to simpler genetic make-up and amenable growth rates. Here, we summarize the recent progress in the synthesis of biofuels, value added chemicals, pharmaceuticals and nutraceuticals via metabolic engineering of microbes.

引用

页码：3760 / 3785

页数：26

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