Advances in mammalian genomics have permitted the application of gene expression profiling approaches to gene discovery for meat quality traits in cattle. The first custom cDNA microarray based on the transcriptome of bovine muscle and fat tissue was developed and applied to animal experimentation and cell culture experimentation between 1999 and 2005. Complementary DNA microarray tools for beef quality research were developed in parallel with bioinformatics tools that permit the analysis of microarray data obtained from complex experimental designs commonly encountered in large animal research. In addition, tools were designed to link gene expression data with gene function in the bovine, such as in vitro models of bovine adipogenesis and bioinformatics tools to map gene networks from expression data. The application of these genomics tools to the study of beef quality has yielded novel knowledge of genes and molecules involved in the processes of intramuscular adipogenesis and protein turnover. This review summarises the current state of knowledge and important lessons derived from bovine genomics initiatives in Australia and around the world.
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Univ Tartu, Inst Mol & Cell Biol, Riia St 23, EE-51010 Tartu, Estonia
Estonian Bioctr, Riia St 23, EE-51010 Tartu, Estonia
Univ Tartu, Fac Med, Lung Clin, Tartu, EstoniaUniv Tartu, Inst Mol & Cell Biol, Riia St 23, EE-51010 Tartu, Estonia
Vooder, Tonu
Valk, Kristjan
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Univ Tartu, Inst Mol & Cell Biol, Riia St 23, EE-51010 Tartu, Estonia
Estonian Bioctr, Riia St 23, EE-51010 Tartu, EstoniaUniv Tartu, Inst Mol & Cell Biol, Riia St 23, EE-51010 Tartu, Estonia
Valk, Kristjan
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Kolde, Raivo
Roosipuu, Retlav
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Tartu Univ Hosp, Dept Pathol, Tartu, EstoniaUniv Tartu, Inst Mol & Cell Biol, Riia St 23, EE-51010 Tartu, Estonia
Roosipuu, Retlav
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Vilo, Jaak
Metspalu, Andres
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Univ Tartu, Inst Mol & Cell Biol, Riia St 23, EE-51010 Tartu, Estonia
Estonian Bioctr, Riia St 23, EE-51010 Tartu, Estonia
Univ Tartu, Estonian Genome Ctr, Tartu, EstoniaUniv Tartu, Inst Mol & Cell Biol, Riia St 23, EE-51010 Tartu, Estonia
Metspalu, Andres
CASE REPORTS IN ONCOLOGY,
2010,
3
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: 255
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