Influence of anisotropic conductivity in the skull and white matter on transcranial direct current stimulation via an anatomically realistic finite element head model

被引:63
|
作者
Suh, Hyun Sang [1 ]
Lee, Won Hee [2 ]
Kim, Tae-Seong [1 ]
机构
[1] Kyung Hee Univ, Dept Biomed Engn, Yongin, Gyeonggi, South Korea
[2] Columbia Univ, Dept Biomed Engn, New York, NY USA
来源
PHYSICS IN MEDICINE AND BIOLOGY | 2012年 / 57卷 / 21期
基金
新加坡国家研究基金会;
关键词
SURFACE-BASED ANALYSIS; STROKE PATIENTS; TISSUE; BRAIN; EEG; SIMULATION; TDCS; MRI; FEM; EEG/MEG;
D O I
10.1088/0031-9155/57/21/6961
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
To establish safe and efficient transcranial direct current stimulation (tDCS), it is of particular importance to understand the electrical effects of tDCS in the brain. Since the current density (CD) and electric field (EF) in the brain generated by tDCS depend on various factors including complex head geometries and electrical tissue properties, in this work, we investigated the influence of anisotropic conductivity in the skull and white matter (WM) on tDCS via a 3D anatomically realistic finite element head model. We systematically incorporated various anisotropic conductivity ratios into the skull and WM. The effects of anisotropic tissue conductivity on the CD and EF were subsequently assessed through comparisons to the conventional isotropic solutions. Our results show that the anisotropic skull conductivity significantly affects the CD and EF distribution: there is a significant reduction in the ratio of the target versus non-target total CD and EF on the order of 12-14%. In contrast, the WM anisotropy does not significantly influence the CD and EF on the targeted cortical surface, only on the order of 1-3%. However, the WM anisotropy highly alters the spatial distribution of both the CD and EF inside the brain. This study shows that it is critical to incorporate anisotropic conductivities in planning of tDCS for improved efficacy and safety.
引用
收藏
页码:6961 / 6980
页数:20
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