REV-ERBs: More Than the Sum of the Individual Parts

被引：21

作者：

Stratmann, Markus ^{[1
,2
]}

Schibler, Ueli ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

[2] Natl Ctr Competence Res Frontiers Genet, CH-1211 Geneva, Switzerland

来源：

CELL METABOLISM | 2012年 / 15卷 / 06期

关键词：

CIRCADIAN TRANSCRIPTION; ALPHA; METABOLISM; CLOCK; BEHAVIOR; BETA;

D O I：

10.1016/j.cmet.2012.05.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.

引用

页码：791 / 793

页数：3

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