In a 7-year-old girl with epilepsia partialis continua (EPC) involving the left face, arm, and leg for 1 year, serial neuroimaging studies showed progressive, brain atrophy. Because medical treatment was ineffective, she underwent a large fronto-temporal surgical resection. Neuropathological examination showed loss of lamination and dysplastic neurons, gliosis, microglial nodules, and perivascular cuffing. Such ''double pathology'' (dysgenesia and a chronic inflammatory process) may have implications for the pathophysiology of Rasmussen's syndrome.
机构:
Univ Colorado, Dept Pathol, Childrens Hosp Colorado, 13123 East 16th Ave,Box 120, Aurora, CO 80045 USAUniv Colorado, Dept Pathol, Childrens Hosp Colorado, 13123 East 16th Ave,Box 120, Aurora, CO 80045 USA
Gilani, Ahmed
Kleinschmidt-DeMasters, Bette K.
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机构:
Univ Colorado, Dept Pathol, Aurora, CO 80045 USA
Univ Colorado, Dept Neurol, Aurora, CO 80045 USA
Univ Colorado, Dept Neurosurg, Aurora, CO 80045 USAUniv Colorado, Dept Pathol, Childrens Hosp Colorado, 13123 East 16th Ave,Box 120, Aurora, CO 80045 USA
机构:
Wayne State Univ, Childrens Hosp Michigan, Detroit Med Ctr, Carman & Ann Adams Dept Pediat,Sch Med, Detroit, MI USA
Wayne State Univ, Childrens Hosp Michigan, Detroit Med Ctr, Carman & Ann Adams Dept Neurol,Sch Med, Detroit, MI USAWayne State Univ, Childrens Hosp Michigan, Detroit Med Ctr, Carman & Ann Adams Dept Pediat,Sch Med, Detroit, MI USA