Methylmercury level in umbilical cords from patients with congenital Minamata disease

被引:55
|
作者
Harada, M
Akagi, H
Tsuda, T
Kizaki, T
Ohno, H
机构
[1] Natl Def Med Coll, Dept Hyg, Tokorozawa, Saitama 3598513, Japan
[2] Kumamoto Univ, Sch Med, Inst Mol Embryol & Genet, Kumamoto 8620976, Japan
[3] Natl Inst Minamata Dis, Minamata 8670008, Japan
[4] Okayama Univ, Sch Med, Dept Hyg, Okayama 7000914, Japan
关键词
methylmercury; congenital Minamata disease; umbilical cord;
D O I
10.1016/S0048-9697(99)00255-7
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
A total of 151 umbilical cords during the period from 1950 to 1969 were collected from the residents of the Minamata area (including 25 patients with congenital Minamata disease) for methylmercury (MeHg) analysis. When the MeHg discharge from the Chisso Company's Minamata factory into the Minamata Bay is compared with the incidence of congenital Minamata disease, the abrupt increase of the former in 1952 [Nishimura H. Chem. Today 1998;323:60-66] was found to precede that of the latter by approximately 2 years, thereby indicating that MeHg is the cause of the disaster. This was confirmed by the elevated levels of MeHg in the umbilical cords from residents of the Minamata area [from 0.35 +/- 0.30 (S.D.) ppm in 1952 to 0.96 +/- 0.75 ppm in 1955], the MeHg levels (1.60 +/- 1.00 ppm) in the cords from patients with congenital Minamata disease showing the highest values [P < 0.01 vs, acquired Minamata disease (0.72 +/- 0.65 ppm), mental retardation (0.74 +/- 0.64 ppm), other diseases (0.22 +/- 0.15 ppm), and no symptoms (0.28 +/- 0.20 ppm), respectively]. Thus, in order to fill a gap, which extends over a long period of time, in studies on environmental Hg pollution, umbilical cord samples were considered to be a useful tool. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:59 / 62
页数:4
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