Anticancer drug design based on plant-derived natural products

被引：65
|
作者：
Lee, KH [1 ]
机构：
[1] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF BIOMEDICAL SCIENCE | 1999年 / 6卷 / 04期
关键词：
anticancer agents; drug design; natural products; synthetic analogs;
D O I：
10.1007/BF02253565
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This review article focuses on recent research in my laboratory on various classes of compounds that possess potent antitumor activity, These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analog synthesis, Structural modification, structure-activity relationship, and mechanism of action studies will be discussed.
引用
收藏
页码：236 / 250
页数：15
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