Comparison of the effects of various contrast media on the chemiluminescence of rat peritoneal macrophages in vitro

The effects of contrast media on the chemiluminescence of rat resident and zymosan-activated macrophages were studied in, vitro. Bilignost, hexabrix, omnipaque, and ultravist in a concentration of 10 mg iodine/ml inhibited the production of active oxygen forms in resident and stimulated macrophages, while magnevist and omniscan in a concentration of 2 mg gadolinium/ml were active only in the resident cells, as evidenced by changes in their chemiluminescence. Bilignost, hexabrix, melitrast, omnipaque, peritrast, triombrast, and ultravist in a concentration of 1 mg iodine/ml and magnevist and omniscan in a concentration of 0.2 mg gadolinium/ml activated the spontaneous chemiluminescence of macrophages to a different degree.