INFLUENCE OF pH ON THE PHYSICO-CHEMICAL, THERMAL AND MECHANICAL PROPERTIES OF POLY(VINYL ALCOHOL)/POLY(ACRYLIC ACID)/ACYCLOVIR FILMS

被引：1
|
作者：
Zepon, Karine Modolon [1 ]
Kanis, Luiz Alberto [1 ]
Soldi, Valdir [2 ]
Salmoria, Gean Vitor [3 ]
机构：
[1] Univ Sul Santa Catarina, BR-88704900 Tubarao, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
[3] Univ Fed Santa Catarina, Dept Engn Mecan, BR-88040900 Florianopolis, SC, Brazil
来源：
QUIMICA NOVA | 2013年 / 36卷 / 02期
关键词：
hydrogel; acyclovir; drug delivery system; DRUG-RELEASE; HYDROGEL; DELIVERY; ALCOHOL);
D O I：
10.1590/S0100-40422013000200003
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
INFLUENCE OF pH ON THE PHYSICO-CHEMICAL, THERMAL AND MECHANICAL PROPERTIES OF POLY(VINYL ALCOHOL)/POLY(ACRYLIC ACID)/ACYCLOVIR FILMS. Drug-loaded films represent an alternative method for the treatment of skin lesions caused by Herpes simplex, since they facilitate delivery of the drug directly at the site of lesion. The objective of this work was to prepare PVA/PAA films containing AC at pH 2.0 and 4.0. The results show that the pH of the film preparations influences the polymer drug interaction kinetic order and the degree of swelling. The mechanism of release of AC from the films obtained at pH 4.0 was anomalous, whereas for the films prepared at pH 2.0 the release followed zero-order kinetics.
引用
收藏
页码：215 / 219
页数：5
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