Neoadjuvant chemoradiotherapy for resectable oesophageal cancer

被引：15
|
作者：
Eyck, B. M. [1 ]
van der Wilk, B. J. [1 ]
Lagarde, S. M. [1 ]
Wijnhoven, B. P. L. [1 ]
Valkema, R. [2 ]
Spaander, M. C. W. [3 ]
Nuyttens, J. J. M. E. [4 ]
van der Gaast, A. [5 ]
van Lanschot, J. J. B. [1 ]
机构：
[1] Univ Med Ctr Rotterdam, Dept Surg, Erasmus MC, Dr Molenwaterpl 40, NL-3000 CA Rotterdam, Netherlands
[2] Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, Erasmus MC, Dr Molenwaterpl 40, NL-3000 CA Rotterdam, Netherlands
[3] Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Erasmus MC, Dr Molenwaterpl 40, NL-3000 CA Rotterdam, Netherlands
[4] Univ Med Ctr Rotterdam, Dept Radiotherapy, Erasmus MC, Dr Molenwaterpl 40, NL-3000 CA Rotterdam, Netherlands
[5] Univ Med Ctr Rotterdam, Dept Med Oncol, Erasmus MC, Dr Molenwaterpl 40, NL-3000 CA Rotterdam, Netherlands
来源：
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2018年 / 36-37卷
关键词：
Chemoradiotherapy; Chemotherapy; Oesophageal cancer; Response prediction; Response evaluation; PHASE-III TRIAL; POSITRON-EMISSION-TOMOGRAPHY; QUALITY-OF-LIFE; LIMITED TRANSHIATAL RESECTION; PATHOLOGICAL RESPONSE; HYPERFRACTIONATED RADIOTHERAPY; PREOPERATIVE CHEMORADIATION; PERIOPERATIVE CHEMOTHERAPY; PLUS SURGERY; THERAPY;
D O I：
10.1016/j.bpg.2018.11.007
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
radiotherapy followed by oesophagectomy. Alternatively, neoadjuvant chemotherapy is used. To date, strong evidence on the superiority of one modality over the other has not been provided. Currently, up to one-third of patients show a pathologically complete response after neoadjuvant chemoradiotherapy. To optimise the efficacy of neoadjuvant treatment for individual patients, prediction of response to neoadjuvant treatment is highly desired, Therefore, several clinical diagnostic modalities have been investigated for early response evaluation, of which positron emission tomography (PET) has been studied most extensively. To identify patients who might benefit from postponing or even omitting surgery, recent advances have been made in evaluating response after completion of neoadjuvant chemoradiotherapy. This review provides an overview of current evidence and recent advances in neoadjuvant chemoradiotherapy for oesophageal cancer and discusses the use of neoadjuvant chemotherapy compared to chemoradiotherapy. Moreover, clinical response evaluation to neoadjuvant chemoradiotherapy is reviewed. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：37 / 44
页数：8
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