Synthesis and Characterization of pH-Sensitive Positive-charge Silica Nanoparticles for Oral Anionic Drug Delivery

The objective of this study is to utilize the pH sensitivity of modified mesoporous silica nanoparticles (MSN) for oral drug delivery. In the first time, a pH-sensitive ionic liquid was synthesized through the quaternization of 3-aminopropyltrimethoxysilane (3-ATMS) with sodium monochloroacetate (SMCA). Then, silica nanoparticle was modified by this pH-sensitive ionic liquid and converted to a pH-sensitive positive-charge silica nanoparticle (PCSN). The nanoparticle was characterized by FTIR and SEM. Naproxen as anionic drug molecules was entrapped in this pH-sensitive positive-charge silica nanoparticles (PCSN) and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIP, pH 7.4).