Synthesis and antiinflammatory activity of 4-amino-2-aryl-5-cyano-6-{3-and 4-(N-phthalimidophenyl)} pyrimidines

Six new 4-amino-5-eyano-2,6-diarylpyrimidines 5a-h has been synthesized in a facile manner by reacting the appropriate arylamidines 4a-d with bisnitriles 3a-e. Reduction of the nitro group of 5a-e using Pd in ethyl acetate furnished 6a-e in good yields. Reaction of 6a-e individually with phthalic anhydride yielded 7a-e in good to excellent yields. The newly synthesized heterocycles were characterized by IR, H-1-NMR and mass spectral data. Compounds 5f-h and 7a-e were also evaluated against inflammation. Pyrimidines 5g, h exhibited better anti inflammatory activity when compared with acetylsalicylic acid (ASA). Phthalimide derivatives 7a-e also presented antiinflammatory activity, and three of them, viz., 7a-c have been found to be twice more active than aspirin. Cytotoxical evaluations of compounds 7a-e using neoplastic cells (NCI-H-292 and Hep-2) presented 41% of growth inhibition of neoplastic cells NCI-H-292. (c) 2006 Elsevier SAS. All rights reserved.