Synthesis of α-acylamino-amide-bis (indolyl) methane heterocycles by sequential one pot condensation-Ugi/Passerini reactions and their antimicrobial evaluation

被引：12
|
作者：
Kaur, Gurpreet [1 ]
Vadekeetil, Anitha [2 ]
Harjai, Kusum [2 ]
Singh, Vasundhara [1 ]
机构：
[1] PEC Univ Technol, Chandigarh 160012, India
[2] Panjab Univ, Chandigarh 160014, India
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 30期
关键词：
Bis(indolyl) methane; Sequential; Ugi reaction; Passerini reaction; Heterocycles; ANALOGS; ALDEHYDES; EFFICIENT; ACID;
D O I：
10.1016/j.tetlet.2015.05.010
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New bis (indolyl) methane based heterocycles were developed by a proficient sequential synthesis in one pot where substituted aromatic aldehydes, isocyanides were varied, producing a library of benzamide and benzoate analogues with multiple points of diversity. The synthesized analogues were tested for their antibacterial potency against gram positive and gram negative pathogenic bacteria. (C) 2015 Published by Elsevier Ltd.
引用
收藏
页码：4445 / 4450
页数：6
相关论文
共 9 条
  • [1] Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities
    Tantak, Mukund P.
    Gupta, Vishakha
    Nikhil, Kumar
    Arun, V.
    Singh, Rajnish Prakash
    Jha, Prabhat Nath
    Shah, Kavita
    Kumar, Dalip
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (13) : 3167 - 3171
  • [2] Synthesis of Bis(indolyl)methane/Dihydropyrimidinone Tethered Bis-Amidic Triazole Hybrid Compounds via One-Pot Sequential Six/Seven Component Ugi-Click Reaction
    Kumar, Sitanshu
    Mangal, Surabhi
    Nosran, Anu
    Harjai, Kusum
    Singh, Vasundhara
    CHEMISTRYSELECT, 2022, 7 (17):
  • [3] Recent Advancement in the Green Synthesis of Bis(indolyl) Methane Via One-pot Multicomponent Condensation Strategy: (A Mini Review)
    Bedi, Pooja
    Kaur, Rajbir
    Bose, Reshmi
    Pakhira, Bholanath
    Roy, Manas
    Pramanik, Tanay
    ORIENTAL JOURNAL OF CHEMISTRY, 2024, 40 (05) : 1207 - 1219
  • [4] Design, one-pot green synthesis and antimicrobial evaluation of novel imidazopyridine bearing pyran bis-heterocycles
    Thakur, Ashima
    Pereira, Gavin
    Patel, Chetananda
    Chauhan, Vinita
    Dhaked, Ram Kumar
    Sharma, Abha
    JOURNAL OF MOLECULAR STRUCTURE, 2020, 1206 (1206)
  • [5] A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
    Rani, M.
    Utreja, D.
    Dhillon, N. K.
    Kaur, K.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (10) : 1527 - 1533
  • [6] A Convenient One-Pot Synthesis of Bis(indolyl)methane Derivatives and Evaluation of Their Nematicidal Activity against the Root Knot Nematode Meloidogyne incognita
    M. Rani
    D. Utreja
    N. K. Dhillon
    K. Kaur
    Russian Journal of Organic Chemistry, 2022, 58 : 1527 - 1533
  • [7] Synthesis of 2-tetrazolylmethyl-tetrahydro-1H-β-carboline methane-linked bis-heterocycles via one pot Ugi-azide/Pictet-Spengler process
    Alvarez-Rodriguez, Nancy V.
    Islas Jacome, Alejandro
    Gamez-Montano, Rocio
    20TH INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY (ECSOC), 2016,
  • [8] One-pot and divergent synthesis of polysubstituted quinolin-2(1H)-ones and oxireno[2,3-c]quinolin-2(1aH,3H,7bH)-ones via sequential Ugi/Knoevenagel condensation/hydrolysis and Ugi/Corey-Chaykovsky epoxidation reactions
    Yang, Mao-Lin
    Pan, Hong-Ling
    Kong, Han-Han
    Ding, Ming-Wu
    ORGANIC CHEMISTRY FRONTIERS, 2022, 9 (21) : 5983 - 5988
  • [9] Bovine serum albumin triggered waste-free aerobic oxidative coupling of thiols into disulphides on water: An extended synthesis of bioactive dithiobis(phenylene)bis(benzylideneimine) via sequential oxidative coupling-condensation reactions in one pot from aminothiophenol and benzaldehyde
    Saima
    Lavekar, Aditya G.
    Kumar, Rajesh
    Sinha, Arun K.
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2015, 116 : 113 - 123
1