Visible-Light Photoredox in Homolytic Aromatic Substitution: Direct Arylation of Arenes with Aryl Halides

被引：129
|
作者：
Cheng, Yannan [1 ]
Gu, Xiangyong [1 ]
Li, Pixu [1 ]
机构：
[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 11期
关键词：
C-H-ARYLATION; FUNCTIONALIZATION; HETEROARENES; BUTOXIDE;
D O I：
10.1021/ol400946k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Direct arylation of unactivated arenes or heteroarenes with aryl halides could be carried out in the presence of potassium tert-butoxide and dimethyl sulfoxide under visible-light irradiation. Ir(ppy)(3) was found to be an effective photoredox catalyst for this reaction. The reactions of aryl iodides occurred at room temperature. Elevated temperature was required for aryl bromides. Homolytic aromatic substitution was proposed to be the operative reaction pathway.
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页码：2664 / 2667
页数：4
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